In six compelling chapters, this book recounts conversations that discuss what is ethical, why it does not occur more often, and how can we improve ethical conduct in our personal and public lives. The conversations include Knowing Ethical Principles, Learning How to Apply Principles in Practice, Moral Reminders, Accountability for Conduct, Addressing Structural Problems, and Ethical Vigilance. Major ethical perspectives are discussed in conversational format, as are fascinating ethical dilemmas taken from actual cases to evaluate and improve our ability to (...) identify ethical principles and make decisions that reflect concerns beyond self-interest. (shrink)

The False Claims Act, 31 U.S.C. § 3729, a post-Civil War law inspired by cases of defense contracting fraud, was revitalized in 1986. Since then it has been used to sue both manufacturers and providers of pharmaceuticals. In some cases, these suits were meant to target offlabel marketing of pharmaceuticals. In 2009, the 11th Circuit rendered a decision in Hopper v. Solvay Pharmaceuticals that dramatically limits the ability of private plaintiff whistle-blowers to bring qui tam suits under the FCA for (...) such marketing. In June 2010, the Supreme Court denied certiorari, making the Circuit court decision final. The Solvay decision creates a significant barrier to certain kinds of qui tam suits, requiring the plaintiff to demonstrate the intent to market off-label, including by showing specific prescriptions that were written as a result of efforts to do so. (shrink)

RationaleSurrogates of critically ill patients often have inaccurate expectations about prognosis. Yet there is little research on how intensive care unit clinicians should discuss prognosis, and existing expert opinion-based recommendations give only general guidance that has not been validated with surrogate decision makers.ObjectiveTo determine the perspectives of key stakeholders regarding how prognostic information should be conveyed in critical illness.MethodsThis was a multicenter study at three academic medical centers in California, Pennsylvania, and Washington. One hundred eighteen key stakeholders completed in-depth semistructured (...) interviews. Participants included 47 surrogates of adult patients with acute respiratory distress syndrome; 45 clinicians working in study ICUs, including physicians, nurses, social workers, and spiritual care providers; and 26 experts in health communication, decision science, ethics, family-centered care, geriatrics, healthcare disparities, palliative care, psychology, psychiatry, and critical care.Measurements and main resultsThere was broad support among surrogates for existing expert recommendations, including truthful prognostic disclosure, emotional support, tailoring the disclosure strategy to each family's needs, and checking for understanding. In addition, stakeholders offered suggestions that add specificity to existing recommendations, including: In addition to conveying prognostic estimates, clinicians should help families "see the prognosis for themselves" by showing families radiographic images and explaining the clinical significance of physical manifestations of severe disease at the bedside. Many physicians did not support using numeric estimates to convey prognosis to families, whereas many surrogates, clinicians from other disciplines, and experts believed numbers could be helpful. Clinicians should conceptualize prognostic communication as an iterative process that begins with a preliminary mention of the possibility of death early in the ICU stay and becomes more detailed as the clinical situation develops. Although prognostic information should be initially disclosed by physicians, other members of the multidisciplinary team-nurses, social workers, and spiritual care providers-should be given explicit role responsibilities to reinforce physicians' prognostications and help families process a poor prognosis emotionally.ConclusionsFamily members, clinicians, and experts identified specific communication behaviors that clinicians should use to discuss prognosis in the critical care setting. These findings extend existing opinion-based recommendations and should guide interventions to improve communication about prognosis in ICUs. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

In this empirical paper, Jay, Stone, Meksin, Merck, Gordon and Hirst examine whether jury deliberations, in which individuals collaboratively recall and discuss evidence of a trial, shape the jurors’ memories. In doing so, Jay and colleagues provide a highly ecologically valid baseline for future investigation into why, how and when selective recall either facilitates remembering or leads to forgetting during jury deliberations. In particular, Jay et al. explore the specific social and cognitive mechanisms that might lead to either memory facilitation (...) (RIFA – Retrieval Induced Facilitation) and forgetting (RIF ‐ Retrieval Induced Forgetting) during jury deliberation. (shrink)

Spiritual messages of Jayēntira Sarasvati, Jagatguru Sankaracharya of Kamakoti, b. 1935, Hindu religious leader.

H. Jay Dinshah, the father of the modern vegan movement in America and founder of American Vegan Society, eloquently explains ethical reasons for veganism. His daughter Anne updates and edits his pioneering writings. Over forty vegan luminaries tell how they were influenced and inspired by Jay. Together they encourage readers to explore ways to promote positive action in the world towards veganism through “dynamic harmlessness.”.

Distributional semantic models (DSMs) are a primary method for distilling semantic information from corpora. However, a key question remains: What types of semantic relations among words do DSMs detect? Prior work typically has addressed this question using limited human data that are restricted to semantic similarity and/or general semantic relatedness. We tested eight DSMs that are popular in current cognitive and psycholinguistic research (positive pointwise mutual information; global vectors; and three variations each of Skip-gram and continuous bag of words (CBOW) (...) using word, context, and mean embeddings) on a theoretically motivated, rich set of semantic relations involving words from multiple syntactic classes and spanning the abstract–concrete continuum (19 sets of ratings). We found that, overall, the DSMs are best at capturing overall semantic similarity and also can capture verb–noun thematic role relations and noun–noun event-based relations that play important roles in sentence comprehension. Interestingly, Skip-gram and CBOW performed the best in terms of capturing similarity, whereas GloVe dominated the thematic role and event-based relations. We discuss the theoretical and practical implications of our results, make recommendations for users of these models, and demonstrate significant differences in model performance on event-based relations. (shrink)

Jay L. Garfield defends two exegetical theses regarding Hume's Treatise on Human Nature. The first is that Book II is the theoretical foundation of the Treatise. Second, Garfield argues that we cannot understand Hume's project without an appreciation of his own understanding of custom, and in particular, without an appreciation of the grounding of his thought about custom in the legal theory and debates of his time.

The first longevity revolution began in the middle of the 19th century, accelerated through the first half of the 20th century, and led to the first and only quantum leap in human life expectancy.In the 20th century alone, life expectancy at birth in most developed nations rose by about 30 years. The first three quarters of the century were notable for gains made at younger and middle ages, and in the last quarter century, old age mortality declined. Nothing in history (...) has ever come close to the magnitude of this benefit to humanity. The rise in life expectancy occurred swiftly because the primary beneficiaries of advances in public health and... (shrink)

Few words in both everyday parlance and theoretical discourse have been as rhapsodically defended or as fervently resisted as "experience." Yet, to date, there have been no comprehensive studies of how the concept of experience has evolved over time and why so many thinkers in so many different traditions have been compelled to understand it. _Songs of Experience _is a remarkable history of Western ideas about the nature of human experience written by one of our best-known intellectual historians. With its (...) sweeping historical reach and lucid comparative analysis—qualities that have made Martin Jay's previous books so distinctive and so successful—_Songs of Experience _explores Western discourse from the sixteenth century to the present, asking why the concept of experience has been such a magnet for controversy. Resisting any single overarching narrative, Jay discovers themes and patterns that transcend individuals and particular schools of thought and illuminate the entire spectrum of intellectual history. As he explores the manifold contexts for understanding experience—epistemological, religious, aesthetic, political, and historical—Jay engages an exceptionally broad range of European and American traditions and thinkers from the American pragmatists and British Marxist humanists to the Frankfurt School and the French poststructuralists, and he delves into the thought of individual philosophers as well, including Montaigne, Bacon, Locke, Hume and Kant, Oakeshott, Collingwood, and Ankersmit. Provocative, engaging, erudite, this key work will be an essential source for anyone who joins the ongoing debate about the material, linguistic, cultural, and theoretical meaning of "experience" in modern cultures. (shrink)

Christie, Jaye; Stuart, Stephen The United States have experienced devastating attacks on church-state separation in recent decades. The intrusion of religion into affairs of state is more blatant than in Australia, but there is mounting evidence that the religious right is gaining momentum here. As former Australian High Court judge, Michael Kirby, has said, 'The principle of secularism is one of the greatest developments in human rights in the world. We must safeguard and protect it, for it can come under (...) threat in contemporary Australia.'. (shrink)

At least two recent collections of essays – Postmodernism and the Enlightenment and What’s Left of Enlightenment?: A Postmodern Question – have responded to postmodern critiques of Enlightenment by arguing that Enlightenment philosophes themselves embraced a number of post-modern themes. This essay situates Kant’s essay Was ist Aufklärung in the context of this recent literature about the appropriate characterization of modernity and the Enlightenment. Adopting an internalist reading of Kant’s Aufklärung essay, this paper observes that Kant is surprisingly ambivalent about (...) who might be Enlightened and unspecific about when Enlightenment might be achieved. The paper argues that this is because Kant is concerned less with elucidating his concept of Enlightenment and more with characterizing a political condition that might provide the conditions for the possibility of Enlightenment. This paper calls this political condition modernity and it is achieved when civil order can be maintained alongside fractious and possibly insoluble public disagreement about matters of conscience, including the nature and possibility of Enlightenment. Thus, the audience for the Aufklärung essay is not the tax collector, soldier or clergyman, but rather the sovereign. Kant enjoins and advises the prince that discord and debate about matters of conscience need not entail any political unrest or upheaval. It is in this restricted sense that the Enlightenment essay is Kant’s Machiavellian moment. (shrink)

The question of Hegel's views on Buddhism and its place within his system must be asked again as the history of effects, transmission, and reception continues to unfold. This unfolding highlights not only Hegel's effect on the Western European reception and understanding of Buddhism (and its sharp orientalist critique), but also the canny use of Hegel's philosophy by certain members of the so-called Kyoto School of Japanese neo-Buddhist philosophy, who, though primarily concerning themselves with Heidegger, were notable in their creative (...) use of Hegel's philosophy of spirit (especially Nishida, Nishitani, Tanabe, and Abe). Our present task is likewise to look back to Hegel's own writing on Buddhism through the lens of the history of its effects—that is, to read Hegel again with his legacy in mind—so that we might, as strange as it may perhaps seem, see things more clearly. Our goal is relatively modest, as it aims only to seek out and coordinate Buddhism within Hegel's history of philosophy. Thus, as we have a proximate goal in mind, we also have an order of importance with respect to Hegel's texts, which, of course, brings the Lectures on the History of Philosophy to the fore. (shrink)

The stakeholder perspective has provided a rich forum for a variety of debates at the intersection of business and society. Scholars gathered for two consecutive years, first in North America, and then in Europe, to discuss the major issues surrounding what has come to be known as stakeholder theory, to attempt to find common ground, and to uncover areas in need of further inquiry. Those meetings led to a list of “tensions” and a call for papers for this special issue (...) to help address them. In this article, we introduce the resulting articles and provide some brief commentary on their importance. We end with a few of our own observations about the stakeholder perspective and stakeholder research. (shrink)

Philosophy of science has the potential to enhance scientific practice, science policy, and science education; moreover, recent research indicates that many philosophers of science think we ought to increase the broader impacts of our work. Yet, there is little to no empirical data on how we are supposed to have an impact. To address this problem, our research team interviewed 35 philosophers of science regarding the impact of their work in science-related domains. We found that face-to-face engagement with scientists and (...) other stakeholders was one of the most—if not the most—effective pathways to impact. Yet, working with non-philosophers and disseminating research outside philosophical venues is not what philosophers are typically trained or incentivized to do. Thus, there is a troublesome tension between the activities that are likely to lead to broader uptake of one’s work and those that are traditionally encouraged and rewarded in philosophy. We suggest several ways that philosophers of science, either as individuals or as a community, can navigate these tensions. (shrink)

Long considered "the noblest of the senses," vision has increasingly come under critical scrutiny by a wide range of thinkers who question its dominance in Western culture. These critics of vision, especially prominent in twentieth-century France, have challenged its allegedly superior capacity to provide access to the world. They have also criticized its supposed complicity with political and social oppression through the promulgation of spectacle and surveillance. Martin Jay turns to this discourse surrounding vision and explores its often contradictory implications (...) in the work of such influential figures as Jean-Paul Sartre, Maurice Merleau-Ponty, Michel Foucault, Jacques Lacan, Louis Althusser, Guy Debord, Luce Irigaray, Emmanuel Levinas, and Jacques Derrida. Jay begins with a discussion of the theory of vision from Plato to Descartes, then considers its role in the French Enlightenment before turning to its status in the culture of modernity. From consideration of French Impressionism to analysis of Georges Bataille and the Surrealists, Roland Barthes's writings on photography, and the film theory of Christian Metz, Jay provides lucid and fair-minded accounts of thinkers and ideas widely known for their difficulty. His book examines the myriad links between the interrogation of vision and the pervasive antihumanist, antimodernist, and counter-enlightenment tenor of much recent French thought. Refusing, however, to defend the dominant visual order, he calls instead for a plurality of "scopic regimes." Certain to generate controversy and discussion throughout the humanities and social sciences, _Downcast Eyes_ will consolidate Jay's reputation as one of today's premier cultural and intellectual historians. (shrink)

For decades, policy-makers in government, development banks and foundations, NGOs, researchers and students have struggled with the problem of how to protect people who are displaced from their homes and livelihoods by development projects. This book addresses these concerns and explores how debates often become deadlocked between 'managerial' and 'movementist' perspectives. Using development ethics to determine the rights and responsibilities of various stakeholders, the authors find that displaced people must be empowered so as to share equitably in benefits rather than (...) being victimized. They propose a governance model for development projects that would transform conflict over displacement into a more manageable collective bargaining process and would empower displaced people to achieve equitable results. Their book will be valuable for readers in a wide range of fields including ethics, development studies, politics and international relations as well as policy making, project management and community development. (shrink)

At Theresa Schiavo's bedside : a guardian's role and reflections.

In lieu of an abstract, here is a brief excerpt of the content:I would like to begin by thanking Gregory LaNave for his analysis of Bonaventure's Itinerarium. His interpretation has helped me clarify my own understanding of that rich text. I would also like to thank the editors of Franciscan Studies who invited this response. It focuses on LaNave's misreading of "symbolic theology," his own "scientific" interpretation of the Itinerarium, and the relationship between scientific and symbolic theology as explained by (...) Bonaventure. Accordingly, I divide my response into three parts: Clarifying the Meaning of Symbolic Theology, Critique of Dr. LaNave's Analysis, and Scientific and Symbolic Theology.Clarifying the Meaning of Symbolic TheologyIn Divine and Created Order in Bonaventure's Theology, I employ the term "symbolic theology" to help the modern reader approach and appreciate Bonaventure's profuse use of symbols in the Itinerarium. Dr. LaNave acknowledges that such an accommodation is valuable: "The symbolic reading of Bonaventure has undoubted merits, not least of which is its attempts to do justice to his deft use of an array of symbols in his theology."In my "attempts to do justice" to the ubiquitous symbols throughout the Itinerarium, I describe "symbolic theology" in two ways. First, I claim that Bonaventure:does not employ symbols to prove anything, rather, he resorts to the effusive nature of symbols to demonstrate ineffable mysteries that elude easy description … symbolic thinking, in its most authentic form, is not a second-best mode of grasping reality but a penetration of its most profound metaphysical structure and dynamics.LaNave seems to have two concerns. On the one hand, since symbols do not "prove anything" he deems them as rather inadequate in describing metaphysical realities. For LaNave, symbols can not be "merely symbolic" if "they are in fact ways to penetrate the real metaphysical structure of the realities in question." The "merely" points to the need for something more, which LaNave identifies as the "objectivity of sensation" according to the "canons of a scientific theology ," In effect, he emphasizes by a threefold repetition that the "objectivity of sensation" can better examine "what is really there." It seems that symbols are less equipped for such a task.On the other hand, LaNave's contrast of "symbolic" with "scientific" seems to confuse what I identified as a general characteristic for the actual methodology I employed to analyze the Itinerarium: an analysis of the analogical triads produced by the threefold method of doubling. Like LaNave, I base my interpretation upon the dialectic of seeing God through and in a mirror . Hence, I disagree that I employ a "symbolic approach to theology." Rather, my approach primarily examines the text's analogical triads.Second, I also comment, "Bonaventure uses symbols to provide the imagination with powerful images with which one may ponder the deepest and highest levels of knowing." As an example, I provide the two symbols of the Seraph and Temple from Isaiah 6:1-2. However, LaNave does not comment on this second description of Bonaventure's "symbolic theology." Instead he states:the mystery revealed in any such symbol points to the whole of the mystery, never to any one part in isolation. For example, one may speak about creation and its relationship to the single creative activity of the Creator; but one must at the same time know that Creator to be the Trinity, and see the analogous presence of the Trinity in the creature. Analytical thinking might try to separate these elements; symbolic thinking always strives to see them implied in each other.To justify his claim, he cites pages 228-29 of Divine and Created Order.These pages do not treat or even mention "symbolic theology." Rather, they explain the terms principium, primum, and primitas, and their relation to the notion of ordo. These three terms concern foundational concepts that shape the ontology, metaphysics, and epistemology of Bonaventure's theology. In effect, LaNave correctly.. (shrink)

Despite the lack of invariance problem (the many‐to‐many mapping between acoustics and percepts), human listeners experience phonetic constancy and typically perceive what a speaker intends. Most models of human speech recognition (HSR) have side‐stepped this problem, working with abstract, idealized inputs and deferring the challenge of working with real speech. In contrast, carefully engineered deep learning networks allow robust, real‐world automatic speech recognition (ASR). However, the complexities of deep learning architectures and training regimens make it difficult to use them to (...) provide direct insights into mechanisms that may support HSR. In this brief article, we report preliminary results from a two‐layer network that borrows one element from ASR, long short‐term memory nodes, which provide dynamic memory for a range of temporal spans. This allows the model to learn to map real speech from multiple talkers to semantic targets with high accuracy, with human‐like timecourse of lexical access and phonological competition. Internal representations emerge that resemble phonetically organized responses in human superior temporal gyrus, suggesting that the model develops a distributed phonological code despite no explicit training on phonetic or phonemic targets. The ability to work with real speech is a major advance for cognitive models of HSR. (shrink)

Ecologist Richard Levins argues population biologists must trade‐off the generality, realism, and precision of their models since biological systems are complex and our limitations are severe. Steven Orzack and Elliott Sober argue that there are cases where these model properties cannot be varied independently of one another. If this is correct, then Levins's thesis that there is a necessary trade‐off between generality, precision, and realism in mathematical models in biology is false. I argue that Orzack and Sober's arguments fail since (...) Levins's thesis concerns the pragmatic features of model building not just the formal properties of models. (shrink)

This chapter explicates Theodor W. Adorno's dialectical engagement with inauthenticity and genuineness, two of the central tropes of his mature philosophy. The chapter discusses the extent to which Adorno's critique of genuineness in Minima Moralia and elsewhere was itself deeply indebted to Walter Benjamin's defense of mechanical reproduction against the aura and his notion of the mimetic faculty. It quickly becomes apparent that many of his “own” ideas betray precisely the kind of inauthenticity that he defended against the jargon. Or (...) if one wants to rely on his critical use of the term, it shows the non-auratic authenticity of the intellectual who knows himself not to be in full possession of his own ideas. Paradoxically, in his very lack of originality, his reworking without entirely duplicating many of his friend's most arresting ideas, Adorno took upon himself the stigma he urged everyone to embrace. (shrink)

While one of John Henry Newman's principal aims in the Grammar of Assent is to explain how men can give a ‘real assent’ to the existence of God, the major part of the actual phenomenology of religious belief in the work is concentrated in the fifth of its ten chapters. Unfortunately, this section of the essay has been overshadowed by the preliminary distinction between real and notional apprehension and by the later invocation of the illative sense; but perhaps the time (...) is now ripe for a closer examination of this central part of Newman's philosophy of religion, which is in many ways the key to the successes and failures of Newman's new method in philosophical theology. (shrink)

For nearly two thousand years Buddhism has mystified and captivated both lay people and scholars alike. Seen alternately as a path to spiritual enlightenment, an system of ethical and moral rubrics, a cultural tradition, or simply a graceful philosophy of life, Buddhism has produced impassioned followers the world over. The Buddhist saint Nagarjuna, who lived in South India in approximately the first century CE, is undoubtedly the most important, influential, and widely studied Mahayana Buddhist philosopher. His many works include texts (...) addressed to lay audiences, letters of advice to kings, and a set of penetrating metaphysical and epistemological treatises. His greatest philosophical work, the Mulamadhyamikakarika--read and studied by philosophers in all major Buddhist schools of Tibet, China, Japan, and Korea--is one of the most influential works in the history of Indian philosophy. Now, in The Foundations of the Philosophy of the Middle Way, Jay L. Garfield provides a clear and and eminently readable translation of Nagarjuna's seminal work, offering those with little of no prior knowledge of Buddhist philosophy a view into the profound logic of the Mulamadhyamikakarika. Translated from the Tibetan, the tradition through which Nagarjuna's philosophical influence has largely been transmitted, Garfield presents a superb translation of Mulamadhyamikakarika in its entirety. Illuminating the systematic character of Nagarjuna's reasoning, as well as the works profundity, Garfield shows how Nagarjuna develops his doctrine that all phenomena are empty of inherent existence and essenceless. But, he argues, phenomena nonetheless exist conventionaly, and that indeed conventional existence and ultimate emptiness are in fact the same thing. This represents the radical understanding of the Buddhist doctrine of the two truths, or two levels of reality. Nagarjuna reinterprets all of Buddhist metaphysics and epistemology through this analytical framework--"a systematic and beautifully elegant philosophical dissection of reality." In turn, Garfield goes on to offer the only verse-by-verse commentary based upon the Indo-Tibetan Prasangika-Madhyamika reading of Nagarjuna, the school most influential in the development of Mahayana philosophy in Tibet, China, Korea, and Japan. Written specifically for the Western reader, the commentary explains Nagarjuna's positions and arguments in the language of Western metaphysics and epistemology, and connects Nagarjuna's concerns tho those of Western philosophers such as Sextus, Hume, and Wittgenstein. A fascinating and accessible translation of the foundational text for all Mahayana Buddhism text, The Fundamental Wisdom of the Middle Way will enlighten all those in search of the essence of reality. (shrink)

Bodhicaryåvatåra was composed by the Buddhist monk scholar Íåntideva at Nalandå University in India sometime during the 8th Century CE. It stands as one the great classics of world philosophy and of Buddhist literature, and is enormously influential in Tibet, where it is regarded as the principal source for the ethical thought of Mahåyåna Buddhism. The title is variously translated, most often as A Guide to the Bodhisattva’s Way of Life or Engaging in the Bodhisattva Deeds, translations that follow the (...) canonical Tibetan translation of the title of the book (Byang chub sems pa’i spyod pa la ‘jug pa) and the commentarial tradition of Tibet. But that translation itself is a bit of a gloss on the original Sanskrit, and I think that a more natural English rendering of the Sanskrit title is simply How to Lead an Awakened Life, and that indeed describes the content of the text admirably. Taking this as the title of the text might also issue in a kind of gestalt shift in our view of the text, allowing us to see it not so much as a characterization of the extraordinary moral life of a saint, but as a guide to moral development open to any of us. So, let’s take that as the English title for now. (shrink)

The roughly two and a half millennia over which we can trace the development of mathematics as a discipline have seen ups and downs in its study; the "ups" have involved varying emphases and interests depending on the problems and the temper of the time. The 19th Century may be characterized as a period of development of rigor and attention to the axiomatic method in mathematics. This focus on the deductive process in mathematics was accompanied by the application of mathematics (...) in the study of the deductive process itself. It is safe, I think, to say that the best-known and most influential of the lines of.. (shrink)